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Issue 1, 2017
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Halogenation of organic compounds using continuous flow and microreactor technology

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Abstract

The halogenation of organic substrates is one the most important transformations in organic synthesis. The most straightforward, inexpensive and atom economic halogenations involve the use of elemental halogens (X2) or hydrogen halides (HX). However, X2 and HX reagents are highly reactive, toxic and corrosive materials. Halogenations using these reagents are usually very fast and exothermic reactions, in which selectivity issues occur. Using continuous flow chemistry halogenations involving X2 and HX can be performed in a safe and controllable manner. Reagents can be accurately dosed even for gas/liquid reactions, and exotherms are easily controlled. Hazardous chemicals can be readily quenched in line avoiding any undesired exposures and significantly enhancing the process safety.

Graphical abstract: Halogenation of organic compounds using continuous flow and microreactor technology

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Article information


Submitted
08 Oct 2016
Accepted
09 Nov 2016
First published
16 Nov 2016

This article is Open Access

React. Chem. Eng., 2017,2, 7-19
Article type
Review Article

Halogenation of organic compounds using continuous flow and microreactor technology

D. Cantillo and C. O. Kappe, React. Chem. Eng., 2017, 2, 7
DOI: 10.1039/C6RE00186F

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