Jump to main content
Jump to site search

Issue 39, 2017, Issue in Progress
Previous Article Next Article

The supranutritional selenium status alters blood glucose and pancreatic redox homeostasis via a modulated selenotranscriptome in chickens (Gallus gallus)

Author affiliations

Abstract

Numerous studies have found that high Selenium (Se) influences the pancreas in animals. Considerable studies suggest that Se status plays an important role in the pancreatic function and regulation of blood glucose in chicks. However, true proof for the effects of the supranutritional Se status on the chicken pancreas through modulating the selenotranscriptome is lacking. 1 day-old chicks were fed a basal diet and Se (0.15 mg, 3.0 mg, or 5.0 mg Se per kg of diet) for 8 weeks. The blood glucose level, tissue Se content, redox homeostasis and mRNA level of the selenoproteome in the pancreas were measured. The supranutritional Se status (3.0 mg kg−1) decreased the blood glucose level and increased the pancreatic antioxidant capacity. The excess Se status (5.0 mg kg−1) increased the blood glucose and Se content and decreased the pancreatic antioxidant capacity. The dietary Se status affected the mRNA levels of 24 selenoproteins and the selenoprotein synthesis related transcription factors in the pancreas. The dietary Se level could modulate the growth performance via affecting the blood glucose level and pancreatic function. Se contributions to chicken growth and the regulation of blood glucose are associated with pancreatic redox homeostasis via a modulated selenotranscriptome in chickens.

Graphical abstract: The supranutritional selenium status alters blood glucose and pancreatic redox homeostasis via a modulated selenotranscriptome in chickens (Gallus gallus)

Back to tab navigation

Supplementary files

Article information


Submitted
23 Feb 2017
Accepted
21 Apr 2017
First published
05 May 2017

This article is Open Access

RSC Adv., 2017,7, 24438-24445
Article type
Paper

The supranutritional selenium status alters blood glucose and pancreatic redox homeostasis via a modulated selenotranscriptome in chickens (Gallus gallus)

L. Xiang, W. Li, L. Wang, C. Cao, N. Li, X. Li, X. Jiang and J. Li, RSC Adv., 2017, 7, 24438 DOI: 10.1039/C7RA02278F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements