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Issue 84, 2017
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Bio-conjugation of graphene quantum dots for targeting imaging

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Abstract

Graphene quantum dots (GQDs) with strong photoluminescence (PL) and chemical modification have attracted tremendous interest for fundamental and applied research owing to their special low-cost production and low toxicity. However, most of the research focused on the GQDs without much targeted design, which limited their applications in specific bio-based fields. Inspired by this fascinating conundrum, we demonstrate GQD-based bio-conjugation. Relying on sedimentation coefficient differences for the density gradient ultracentrifuge (DGU) separation of conjugates with different proteins, ultra-purified conjugates were obtained. We demonstrate the first targeted imaging in both cells and tissue models with single or multi color staining, which shows universality for different kinds of biomolecules.

Graphical abstract: Bio-conjugation of graphene quantum dots for targeting imaging

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Publication details

The article was received on 31 Oct 2017, accepted on 15 Nov 2017 and first published on 21 Nov 2017


Article type: Paper
DOI: 10.1039/C7RA11963A
RSC Adv., 2017,7, 53532-53536
  • Open access: Creative Commons BY license
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    Bio-conjugation of graphene quantum dots for targeting imaging

    F. Jia, S. Lv and S. Xu, RSC Adv., 2017, 7, 53532
    DOI: 10.1039/C7RA11963A

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