Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 45, 2017
Previous Article Next Article

Intramolecular cyclization of N-allyl propiolamides: a facile synthetic route to highly substituted γ-lactams (a review)

Author affiliations

Abstract

The development of simple and efficient methods for construction of substituted γ-lactams is an important synthetic goal because such ring skeletons are present in numerous natural compounds that display diverse biological activities. Intramolecular cyclization of N-allyl propiolamides is an efficient, economic, and operationally simple strategy for the synthesis of the titled compounds. In the present review we will discuss recent advances in the synthesis of functionalized γ-lactam derivatives from these easily accessible and versatile building blocks with the emphasis on the mechanistic aspects of the reactions.

Graphical abstract: Intramolecular cyclization of N-allyl propiolamides: a facile synthetic route to highly substituted γ-lactams (a review)

Back to tab navigation

Article information


Submitted
15 Mar 2017
Accepted
04 May 2017
First published
30 May 2017

This article is Open Access

RSC Adv., 2017,7, 28407-28418
Article type
Review Article

Intramolecular cyclization of N-allyl propiolamides: a facile synthetic route to highly substituted γ-lactams (a review)

S. Soleimani-Amiri, E. Vessally, M. Babazadeh, A. Hosseinian and L. Edjlali, RSC Adv., 2017, 7, 28407
DOI: 10.1039/C7RA03075D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements