Jump to main content
Jump to site search

Issue 52, 2017
Previous Article Next Article

Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons

Author affiliations

Abstract

The excess use of nimesulide (NIM) causes acute side effects to gastrointestinal, central nervous and genitourinary systems and hence its rapid, sensitive determination is highly important. We describe a robust electrochemical sensor based on electrochemically reduced graphene oxide nanoribbons (ER-GONRs) modified on a screen-printed carbon electrode (SPCE) for detecting NIM in pharmaceutical formulations and biological medium. Compared with parental multiwalled carbon nanotubes (MWCNTs), ER-GONRs possess rich edge defects, abundant functional groups, high area-normalized edge-plane structures and chemically active sites and hence they can be a superior electrocatalyst and signal amplifier for electroanalytical applications. ER-GONRs/SPCE exhibited excellent sensing performance towards NIM. The linear range was 1.0 × 10−8 to 1.50 × 10−3 M and the detection limit was 3.50 (±1.57) nM. In addition, the ER-GONRs/SPCE showed excellent real-time sensing applications in NIM tablet and human urine samples, which could find potential applicability in drug and clinical analysis. The combined advantages of SPCE technology and ER-GONRs make this method a robust, low-cost, reproducible, sensitive and easy-to-use sensor.

Graphical abstract: Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons

Back to tab navigation

Publication details

The article was received on 08 Mar 2017, accepted on 27 May 2017 and first published on 29 Jun 2017


Article type: Paper
DOI: 10.1039/C7RA02844J
RSC Adv., 2017,7, 33043-33051
  • Open access: Creative Commons BY license
  •   Request permissions

    Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons

    M. Govindasamy, V. Mani, S. Chen, T. Maiyalagan, S. Selvaraj, T. Chen, S. Lee and W. Chang, RSC Adv., 2017, 7, 33043
    DOI: 10.1039/C7RA02844J

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements