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Issue 39, 2017, Issue in Progress
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A silk fibroin hydrogel with reversible sol–gel transition

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Abstract

In this report, a novel silk fibroin hydrogel with a reversible sol–gel transition capacity is presented, in which the base material of this reversible hydrogel is hydrophilic silk fibroin (HSF) obtained by immersing a dried regenerated Bombyx mori silk fibroin (SF) condensate in deionized water (DI water) and collecting its lixivium. The resulting HSF sol can exhibit an enhanced sol–gel transition within several hours at suitable temperatures (25–50 °C) without any exterior additive, even at extremely low concentrations (<0.2%, w/v). The HSF gel can perform thixotropic, reversible gel–sol transitions triggered by a facile cycled shear-thinning and resting procedure. Reversible sol–gel transition kinetics analyses and dynamic measurements of the micro-structure transformation during the transition demonstrate that both the β-sheet self-assembling process and metastable hydrogen bonding (H-bond) interactions among these large scale β-sheet aggregates play essential roles in the significant enhancement of the reversible HSF sol–gel transition. Due to the reversible, thixotropic sol–gel transitions and suitable viscoelasticity of its shear-thinning system for matching random sizes/shapes, the HSF system is possibly an alternative injectable hydrogel for applications in 3-dimensional (3D) cell culture and tissue repair in situ.

Graphical abstract: A silk fibroin hydrogel with reversible sol–gel transition

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Article information


Submitted
06 Mar 2017
Accepted
06 Apr 2017
First published
05 May 2017

This article is Open Access

RSC Adv., 2017,7, 24085-24096
Article type
Paper

A silk fibroin hydrogel with reversible sol–gel transition

Z. Yin, F. Wu, T. Xing, V. K. Yadavalli, S. C. Kundu and S. Lu, RSC Adv., 2017, 7, 24085
DOI: 10.1039/C7RA02682J

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