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Issue 15, 2017, Issue in Progress
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The intriguing journey of gH625-dendrimers

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Abstract

The knowledge of the mechanism used by vectors to gain access to cell interiors is key to the development of effective drug delivery tools for different pathologies. The role of the initial interaction with the membrane bilayer is widely recognized, although not fully understood. We use neutron reflectivity experiments and internalization studies with cells to reveal the extent of interaction of dendrimers functionalized with the peptide gH625 with biomimetic membranes. We further investigate the internalization by use of Caco-2 cells for assessing the membrane permeability properties of the peptide–dendrimer construct. Neutron reflectivity allowed for the hypothesis that the peptide–dendrimer is able to pass across the bilayer which was confirmed via permeability studies. We find that gH625-dendrimers interact more strongly with cholesterol containing membranes. The advances in our understanding of the mechanism of drug uptake are extremely useful to push further the design of new drug delivery systems.

Graphical abstract: The intriguing journey of gH625-dendrimers

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Article information


Submitted
19 Dec 2016
Accepted
20 Jan 2017
First published
30 Jan 2017

This article is Open Access

RSC Adv., 2017,7, 9106-9114
Article type
Paper

The intriguing journey of gH625-dendrimers

A. Falanga, L. Lombardi, R. Tarallo, G. Franci, E. Perillo, L. Palomba, M. Galdiero, D. Pontoni, G. Fragneto, M. Weck and S. Galdiero, RSC Adv., 2017, 7, 9106
DOI: 10.1039/C6RA28405A

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