Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 15, 2017, Issue in Progress
Previous Article Next Article

The intriguing journey of gH625-dendrimers

Author affiliations


The knowledge of the mechanism used by vectors to gain access to cell interiors is key to the development of effective drug delivery tools for different pathologies. The role of the initial interaction with the membrane bilayer is widely recognized, although not fully understood. We use neutron reflectivity experiments and internalization studies with cells to reveal the extent of interaction of dendrimers functionalized with the peptide gH625 with biomimetic membranes. We further investigate the internalization by use of Caco-2 cells for assessing the membrane permeability properties of the peptide–dendrimer construct. Neutron reflectivity allowed for the hypothesis that the peptide–dendrimer is able to pass across the bilayer which was confirmed via permeability studies. We find that gH625-dendrimers interact more strongly with cholesterol containing membranes. The advances in our understanding of the mechanism of drug uptake are extremely useful to push further the design of new drug delivery systems.

Graphical abstract: The intriguing journey of gH625-dendrimers

Back to tab navigation

Publication details

The article was received on 19 Dec 2016, accepted on 20 Jan 2017 and first published on 30 Jan 2017

Article type: Paper
DOI: 10.1039/C6RA28405A
RSC Adv., 2017,7, 9106-9114
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    The intriguing journey of gH625-dendrimers

    A. Falanga, L. Lombardi, R. Tarallo, G. Franci, E. Perillo, L. Palomba, M. Galdiero, D. Pontoni, G. Fragneto, M. Weck and S. Galdiero, RSC Adv., 2017, 7, 9106
    DOI: 10.1039/C6RA28405A

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author