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Issue 1, 2017
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Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

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Abstract

A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.

Graphical abstract: Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

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Publication details

The article was received on 14 Nov 2016, accepted on 07 Dec 2016 and first published on 07 Dec 2016


Article type: Communication
DOI: 10.1039/C6RA26771H
RSC Adv., 2017,7, 132-136
  • Open access: Creative Commons BY license
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    Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

    M. Gisbert-Garzaran, D. Lozano, M. Vallet-Regí and M. Manzano, RSC Adv., 2017, 7, 132
    DOI: 10.1039/C6RA26771H

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