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Issue 11, 2017
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Palladium catalyzed C(sp3)–H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

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Abstract

It still remains a major challenge to apply free primary amino groups as the directing group for aliphatic C–H functionalization. In this article, we used the protonation strategy to control the binding ability of primary amines and realized free amino group directed inert aliphatic C–H acetoxylation in good chemo- and regio-selectivity. This methodology provided a straightforward approach from primary amines to γ-amino alcohols.

Graphical abstract: Palladium catalyzed C(sp3)–H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

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Supplementary files

Article information


Submitted
13 Jun 2017
Accepted
17 Jul 2017
First published
27 Jul 2017

Org. Chem. Front., 2017,4, 2097-2101
Article type
Research Article

Palladium catalyzed C(sp3)–H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

K. Chen, D. Wang, Z. Li, Z. Liu, F. Pan, Y. Zhang and Z. Shi, Org. Chem. Front., 2017, 4, 2097
DOI: 10.1039/C7QO00432J

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