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Issue 10, 2017
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An improved methodology for the synthesis of 1α,25-dihydroxy-20-epi-vitamin D3 (MC 1288) and Gemini analog Ro-438-3582

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Abstract

Control over the C-20 stereochemistry allows a versatile method to introduce novel side-chains into the vitamin D scaffold. Using our building blocks containing stereodefined stereochemistry at C-20 we demonstrated that we could improve the current synthesis of calcitriol analogs with potentially interesting biological properties.

Graphical abstract: An improved methodology for the synthesis of 1α,25-dihydroxy-20-epi-vitamin D3 (MC 1288) and Gemini analog Ro-438-3582

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Article information


Submitted
16 May 2017
Accepted
02 Jul 2017
First published
03 Jul 2017

Org. Chem. Front., 2017,4, 1999-2001
Article type
Research Article

An improved methodology for the synthesis of 1α,25-dihydroxy-20-epi-vitamin D3 (MC 1288) and Gemini analog Ro-438-3582

H. Santalla, A. Martínez, F. Garrido, G. Gómez and Y. Fall, Org. Chem. Front., 2017, 4, 1999
DOI: 10.1039/C7QO00381A

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