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Issue 3, 2017
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Rhodium-catalyzed regiospecific C–H ortho-phenylation of benzoic acids with Cu/air as an oxidant

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Abstract

The development of an efficient and practical synthetic approach for the regiospecific C–H ortho-phenylation of aromatic carboxylic acids without the use of silver or costly coupling partners is reported. The rhodium-catalyzed C–H phenylation proceeded in the presence of Cu/air as a terminal oxidant. In most cases, numerous inactivated benzoic acids could couple with low-cost NaBPh4 to obtain good to excellent yields.

Graphical abstract: Rhodium-catalyzed regiospecific C–H ortho-phenylation of benzoic acids with Cu/air as an oxidant

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Article information


Submitted
27 Oct 2016
Accepted
16 Dec 2016
First published
16 Dec 2016

Org. Chem. Front., 2017,4, 417-420
Article type
Research Article

Rhodium-catalyzed regiospecific C–H ortho-phenylation of benzoic acids with Cu/air as an oxidant

S. Li, G. Deng, F. Yin, C. Li and H. Gong, Org. Chem. Front., 2017, 4, 417 DOI: 10.1039/C6QO00663A

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