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Issue 46, 2017
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A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

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Abstract

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. Amine product concentrations of up to 19.6 mM were achieved. The preparative scale amination of cyclohexane was also demonstrated with a space–time yield of 2 g L−1 d−1.

Graphical abstract: A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

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Article information


Submitted
17 Oct 2017
Accepted
10 Nov 2017
First published
10 Nov 2017

Org. Biomol. Chem., 2017,15, 9790-9793
Article type
Communication

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

M. Tavanti, J. Mangas-Sanchez, S. L. Montgomery, M. P. Thompson and N. J. Turner, Org. Biomol. Chem., 2017, 15, 9790
DOI: 10.1039/C7OB02569F

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