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Issue 36, 2017
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Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

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Abstract

Three divergent Direct Imine Acylation (DIA) procedures are reported that allow the selective generation of δ-lactams, β-lactams and tetrahydropyrimidinones (via a novel three-component coupling) from imine and carboxylic acid precursors. All operate via initial N-acyliminium ion formation and diverge depending on the reaction conditions and nature of the substrates.

Graphical abstract: Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

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Article information


Submitted
16 Aug 2017
Accepted
29 Aug 2017
First published
30 Aug 2017

Org. Biomol. Chem., 2017,15, 7527-7532
Article type
Communication

Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

J. A. Rossi-Ashton, R. J. K. Taylor and W. P. Unsworth, Org. Biomol. Chem., 2017, 15, 7527
DOI: 10.1039/C7OB02039B

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