Jump to main content
Jump to site search

Issue 26, 2017
Previous Article Next Article

Late-stage divergent synthesis and antifouling activity of geraniol–butenolide hybrid molecules

Author affiliations

Abstract

Hybrid molecules consisting of geraniol and butenolide were designed and synthesized by the late-stage divergent strategy. In the synthetic route, ring-closing metathesis was utilized for the construction of a butenolide moiety. A biological evaluation of the eight synthetic hybrid compounds revealed that these molecules exhibit antifouling activity against the cypris larvae of the barnacle Balanus (Amphibalanus) amphitrite with EC50 values of 0.30–1.31 μg mL−1. These results show that hybridization of the geraniol and butenolide structural motifs resulted in the enhancement of the antifouling activity.

Graphical abstract: Late-stage divergent synthesis and antifouling activity of geraniol–butenolide hybrid molecules

Back to tab navigation

Supplementary files

Article information


Submitted
12 May 2017
Accepted
13 Jun 2017
First published
13 Jun 2017

Org. Biomol. Chem., 2017,15, 5549-5555
Article type
Paper

Late-stage divergent synthesis and antifouling activity of geraniol–butenolide hybrid molecules

H. Takamura, T. Ohashi, T. Kikuchi, N. Endo, Y. Fukuda and I. Kadota, Org. Biomol. Chem., 2017, 15, 5549
DOI: 10.1039/C7OB01160A

Social activity

Search articles by author

Spotlight

Advertisements