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Issue 23, 2017
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Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application

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Abstract

Tetrafluoroethylene-containing azides are accessed in two steps (one pot) from tetrafluoroalkyl bromides by metalation and reaction with electrophilic azides. Subsequent copper(I)-catalyzed azide–alkyne cycloaddition afforded N-tetrafluoroethyl and N-tetrafluoroethylene 4-substituted 1,2,3-triazoles. In addition, the protocol for the synthesis of 4,5-disubstituted 1,2,3-triazoles is presented.

Graphical abstract: Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application

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Article information


Submitted
11 May 2017
Accepted
18 May 2017
First published
18 May 2017

This article is Open Access

Org. Biomol. Chem., 2017,15, 4962-4965
Article type
Communication

Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application

S. Voltrová, M. Muselli, J. Filgas, V. Matoušek, B. Klepetářová and P. Beier, Org. Biomol. Chem., 2017, 15, 4962
DOI: 10.1039/C7OB01151B

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