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Issue 29, 2017
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Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A

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Abstract

Synthesis of the antimicrobial marine natural product halocyamine A has been achieved utilizing a combination of Sonogashira coupling, ruthenium complex/ytterbium triflate catalyzed hydroamidation and solid-phase peptide synthesis (SPPS) chemistry. The synthetic natural product exhibited only modest levels of antibacterial activities but significant antioxidant activity.

Graphical abstract: Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A

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Supplementary files

Article information


Submitted
08 May 2017
Accepted
04 Jul 2017
First published
04 Jul 2017

This article is Open Access

Org. Biomol. Chem., 2017,15, 6194-6204
Article type
Paper

Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A

H. K. H. Fong, J. M. Brunel, A. Longeon, M. Bourguet-Kondracki, D. Barker and B. R. Copp, Org. Biomol. Chem., 2017, 15, 6194
DOI: 10.1039/C7OB01122A

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    [Original citation] - Published by The Royal Society of Chemistry.

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