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Issue 1, 2017
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Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus

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Abstract

Deuterium and carbon-13 labelled glycerols have been fed to Streptomyces calvus fermentations and isotope incorporation into the fluorine containing antibiotic nucleocidin have been evaluated by 19F-NMR. A single deuterium atom was incorporated from [2H5]- and (R)-[2H2]-glycerol into C-5′ of the antibiotic, suggesting that an oxidation occurs at this carbon after ribose ring assembly from glycerol (pentose phosphate pathway), during nucleocidin biosynthesis.

Graphical abstract: Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus

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Supplementary files

Article information


Submitted
19 Oct 2016
Accepted
07 Nov 2016
First published
09 Nov 2016

Org. Biomol. Chem., 2017,15, 61-64
Article type
Communication

Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus

A. Bartholomé, J. E. Janso, U. Reilly and D. O'Hagan, Org. Biomol. Chem., 2017, 15, 61
DOI: 10.1039/C6OB02291J

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