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Issue 46, 2017
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Nicking enzyme-controlled toehold regulation for DNA logic circuits

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Abstract

DNA strand displacement is widely used in DNA-related nanoengineering for its remarkable specificity and predictability. We report a nicking enzyme-assisted mechanism to regulate strand displacement, where DNA toeholds are dynamically controlled. To demonstrate the strategy, a protein/DNA-based Boolean operation system is constructed and based on it a two-channel multiplexer controlled by three different nicking enzymes is realized. The proposed regulatory mechanism can be used for switch logic statement and bridges protein and DNA logic circuits.

Graphical abstract: Nicking enzyme-controlled toehold regulation for DNA logic circuits

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Publication details

The article was received on 31 Aug 2017, accepted on 12 Nov 2017 and first published on 15 Nov 2017


Article type: Communication
DOI: 10.1039/C7NR06484E
Nanoscale, 2017,9, 18223-18228

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    Nicking enzyme-controlled toehold regulation for DNA logic circuits

    L. Pan, Z. Wang, Y. Li, F. Xu, Q. Zhang and C. Zhang, Nanoscale, 2017, 9, 18223
    DOI: 10.1039/C7NR06484E

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