Jump to main content
Jump to site search

Issue 47, 2017
Previous Article Next Article

Tomographic magnetic particle imaging of cancer targeted nanoparticles

Author affiliations


Magnetic Particle Imaging (MPI) is an emerging, whole body biomedical imaging technique, with sub-millimeter spatial resolution and high sensitivity to a biocompatible contrast agent consisting of an iron oxide nanoparticle core and a biofunctionalized shell. Successful application of MPI for imaging of cancer depends on the nanoparticles (NPs) accumulating at tumors at sufficient levels relative to other sites. NPs’ physiochemical properties such as size, crystallographic structure and uniformity, surface coating, stability, blood circulation time and magnetization determine the efficacy of their tumor accumulation and MPI signal generation. Here, we address these criteria by presenting strategies for the synthesis and surface functionalization of efficient MPI tracers, that can target a typical murine brain cancer model and generate three dimensional images of these tumors with very high signal-to-noise ratios (SNR). Our results showed high contrast agent sensitivities that enabled us to detect 1.1 ng of iron (SNR ∼ 3.9) and enhance the spatial resolution to about 600 μm. The biodistribution of these NPs was also studied using near-infrared fluorescence (NIRF) and single-photon emission computed tomography (SPECT) imaging. NPs were mainly accumulated in the liver and spleen and did not show any renal clearance. This first pre-clinical study of cancer targeted NPs imaged using a tomographic MPI system in an animal model paves the way to explore new nanomedicine strategies for cancer diagnosis and therapy, using clinically safe magnetic iron oxide nanoparticles and MPI.

Graphical abstract: Tomographic magnetic particle imaging of cancer targeted nanoparticles

Back to tab navigation

Supplementary files

Article information

27 Jul 2017
19 Oct 2017
First published
20 Oct 2017

Nanoscale, 2017,9, 18723-18730
Article type

Tomographic magnetic particle imaging of cancer targeted nanoparticles

H. Arami, E. Teeman, A. Troksa, H. Bradshaw, K. Saatchi, A. Tomitaka, S. S. Gambhir, U. O. Häfeli, D. Liggitt and K. M. Krishnan, Nanoscale, 2017, 9, 18723
DOI: 10.1039/C7NR05502A

Social activity

Search articles by author