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Issue 16, 2017
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Graphene quantum dots for detecting monomeric amyloid peptides

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Abstract

Detection of the concentration of amyloid monomers is of great importance in the diagnosis of amyloidogenesis. Herein, we propose a method to detect the concentration of amyloid β (Aβ) peptide monomers by utilizing the fluorescence characteristics of graphene quantum dots (GQDs). The linear dependence of the photoluminescence (PL) intensity of GQDs on the Aβ monomer concentration can be identified. It can be further illustrated that both monomeric and fibrillar Aβ peptides can be monitored by using GQDs. Conventional fluorescent dyes, such as thioflavin T (ThT), usually undergo co-incubation with amyloid peptides, which could lead to disturbance of the aggregation because of their inhibitory effect. Similar Aβ aggregation dynamics observed by using GQDs and ThT demonstrated the feasibility of the GQD-based detection method without co-incubation with soluble amyloid peptide monomers. The utilization of GQDs as a novel probe monitoring amyloid monomers could be applied in pathological detection and diagnosis of degenerative diseases and other conformational disorders.

Graphical abstract: Graphene quantum dots for detecting monomeric amyloid peptides

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Supplementary files

Publication details

The article was received on 31 Dec 2016, accepted on 18 Mar 2017 and first published on 24 Mar 2017


Article type: Communication
DOI: 10.1039/C6NR10017A
Nanoscale, 2017,9, 5044-5048

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    Graphene quantum dots for detecting monomeric amyloid peptides

    H. Huang, P. Li, M. Zhang, Y. Yu, Y. Huang, H. Gu, C. Wang and Y. Yang, Nanoscale, 2017, 9, 5044
    DOI: 10.1039/C6NR10017A

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