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Issue 10, 2017
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Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream

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Abstract

Surfactant-stripped, nanoformulated naphthalocyanines (nanonaps) can be formed with Pluronic F127 and low temperature membrane processing, resulting in dispersed frozen micelles with extreme contrast in the near infrared region. Here, we demonstrate that nanonaps can be used for multifunctional cancer theranostics. This includes lymphatic mapping and whole tumor photoacoustic imaging following intradermal or intravenous injection in rodents. Without further modification, pre-formed nanonaps were used for positron emission tomography and passively accumulated in subcutaneous murine tumors. Because the nanonaps used absorb light beyond the visible range, a topical upconversion skin cream was developed for anti-tumor photothermal therapy with laser placement that can be guided by the naked eye.

Graphical abstract: Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream

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Supplementary files

Article information


Submitted
01 Dec 2016
Accepted
13 Feb 2017
First published
15 Feb 2017

Nanoscale, 2017,9, 3391-3398
Article type
Communication

Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream

Y. Zhang, H. Hong, B. Sun, K. Carter, Y. Qin, W. Wei, D. Wang, M. Jeon, J. Geng, R. J. Nickles, G. Chen, P. N. Prasad, C. Kim, J. Xia, W. Cai and J. F. Lovell, Nanoscale, 2017, 9, 3391
DOI: 10.1039/C6NR09321C

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