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Issue 1, 2017
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Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

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Abstract

Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.

Graphical abstract: Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

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Article information


Submitted
21 Oct 2016
Accepted
19 Nov 2016
First published
24 Nov 2016

Nanoscale, 2017,9, 99-103
Article type
Communication

Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

G. Ferrauto, F. Carniato, E. Di Gregorio, L. Tei, M. Botta and S. Aime, Nanoscale, 2017, 9, 99
DOI: 10.1039/C6NR08282C

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