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Issue 1, 2017
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Gadolinium oxysulfide-coated gold nanorods with improved stability and dual-modal magnetic resonance/photoacoustic imaging contrast enhancement for cancer theranostics

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Abstract

Gold nanorods (GNRs) are emerging as a promising nanoplatform for cancer theranostics because of their unique optical properties. However, they still suffer from many limitations, such as high cytotoxicity, low thermodynamic and biological stability, and a tedious process for integrating other imaging modalities, for further practical biomedical applications. In this work, a strategy by one-step coating of Gd2O2S around GNRs is reported to address these limitations of GNRs. After the coating of the Gd2O2S shell, the as-fabricated Gd2O2S coated GNRs (GNRs@Gd2O2S) show enhanced biocompatibility and photostability, and tunable localized surface plasmon resonance. The strong absorption in the near-infrared region renders GNRs@Gd2O2S outstanding photoacoustic imaging and photothermal therapy capabilities. Moreover, owing to the T1 shortening ability of Gd2O2S, the GNRs@Gd2O2S also show an excellent T1 MRI contrast performance. The GNRs@Gd2O2S thus can serve as a versatile nanoplatform for cancer theranostics combining dual-modal imaging and photothermal therapy.

Graphical abstract: Gadolinium oxysulfide-coated gold nanorods with improved stability and dual-modal magnetic resonance/photoacoustic imaging contrast enhancement for cancer theranostics

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Supplementary files

Article information


Submitted
21 Oct 2016
Accepted
22 Nov 2016
First published
22 Nov 2016

Nanoscale, 2017,9, 56-61
Article type
Communication

Gadolinium oxysulfide-coated gold nanorods with improved stability and dual-modal magnetic resonance/photoacoustic imaging contrast enhancement for cancer theranostics

T. Guo, Y. Lin, Z. Li, S. Chen, G. Huang, H. Lin, J. Wang, G. Liu and H. Yang, Nanoscale, 2017, 9, 56
DOI: 10.1039/C6NR08281E

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