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Issue 14, 2017
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A simple and facile NMR method for the determination of hydrogen bonding by amide N–H protons in protein models and other compounds

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Abstract

It is shown that measurements of the 1H chemical shifts of amide N–H protons in chloroform and in DMSO solvents are sufficient to determine the extent of hydrogen bonding of the N–H protons in a variety of compounds containing the amide group. Two recent examples are presented from protein and structural chemistry.

Graphical abstract: A simple and facile NMR method for the determination of hydrogen bonding by amide N–H protons in protein models and other compounds

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Publication details

The article was received on 29 Mar 2017, accepted on 11 Jun 2017 and first published on 14 Jun 2017


Article type: Letter
DOI: 10.1039/C7NJ01044C
New J. Chem., 2017,41, 6064-6066
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    A simple and facile NMR method for the determination of hydrogen bonding by amide N–H protons in protein models and other compounds

    M. H. Abraham and R. J. Abraham, New J. Chem., 2017, 41, 6064
    DOI: 10.1039/C7NJ01044C

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