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Issue 11, 2017
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Recent structural insights into the function of copper nitrite reductases

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Abstract

Copper nitrite reductases (CuNiR) carry out the first committed step of the denitrification pathway of the global nitrogen cycle, the reduction of nitrite (NO2) to nitric oxide (NO). As such, they are of major agronomic and environmental importance. CuNiRs occur primarily in denitrifying soil bacteria which carry out the overall reduction of nitrate to dinitrogen. In this article, we review the insights gained into copper nitrite reductase (CuNiR) function from three dimensional structures. We particularly focus on developments over the last decade, including insights from serial femtosecond crystallography using X-ray free electron lasers (XFELs) and from the recently discovered 3-domain CuNiRs.

Graphical abstract: Recent structural insights into the function of copper nitrite reductases

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Article information


Submitted
05 May 2017
Accepted
27 Jun 2017
First published
28 Jun 2017

This article is Open Access

Metallomics, 2017,9, 1470-1482
Article type
Critical Review

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