Jump to main content
Jump to site search

Issue 6, 2017
Previous Article Next Article

Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c

Author affiliations

Abstract

The soluble mycobacterial carbonic anhydrases Rv3588c and Rv1284 belong to a different class of carbonic anhydrases than those found in humans, making them attractive drug targets by using the inherent differences in the folds of the different classes. By screening a natural product library, we identified naphthoquinone derivatives as a novel non-classical inhibitor scaffold of mycobacterial carbonic anhydrases that lack the sulfonamide/sulfamate group and thus did not affect human carbonic anhydrase II.

Graphical abstract: Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c

Back to tab navigation

Supplementary files

Article information


Submitted
22 Feb 2017
Accepted
08 May 2017
First published
12 May 2017

Med. Chem. Commun., 2017,8, 1318-1321
Article type
Research Article

Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c

M. A. Dallaston, S. Rajan, J. Chekaiban, M. Wibowo, M. Cross, M. J. Coster, R. A. Davis and A. Hofmann, Med. Chem. Commun., 2017, 8, 1318
DOI: 10.1039/C7MD00090A

Search articles by author

Spotlight

Advertisements