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Issue 14, 2017
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Battery operated preconcentration-assisted lateral flow assay

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Paper-based analytical devices (e.g. lateral flow assays) are highly advantageous as portable diagnostic systems owing to their low costs and ease of use. Because of their low sensitivity and detection limits for biomolecules, these devices have several limitations in applications for real-field diagnosis. Here, we demonstrate a paper-based preconcentration enhanced lateral flow assay using a commercial β-hCG-based test. Utilizing a simple 9 V battery operation with a low power consumption of approximately 81 μW, we acquire a 25-fold preconcentration factor, demonstrating a clear sensitivity enhancement in the colorimetric lateral flow assay; consequently, clear colors are observed in a rapid kit test line, which cannot be monitored without preconcentration. This device can also facilitate a semi-quantitative platform using the saturation value and/or color intensity in both paper-based colorimetric assays and smartphone-based diagnostics.

Graphical abstract: Battery operated preconcentration-assisted lateral flow assay

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Publication details

The article was received on 11 Jan 2017, accepted on 31 May 2017 and first published on 31 May 2017

Article type: Paper
DOI: 10.1039/C7LC00036G
Lab Chip, 2017,17, 2451-2458

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    Battery operated preconcentration-assisted lateral flow assay

    C. Kim, Y. K. Yoo, S. I. Han, J. Lee, D. Lee, K. Lee, K. S. Hwang, K. H. Lee, S. Chung and J. H. Lee, Lab Chip, 2017, 17, 2451
    DOI: 10.1039/C7LC00036G

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