Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 2, 2017
Previous Article Next Article

One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

Author affiliations

Abstract

Imine reductases (IREDs) show great potential as catalysts for reductive amination of ketones to produce chiral secondary amines. In this work, we explored this potential and synthesized the pharmaceutically relevant (R)-rasagiline in high yields (up to 81%) and good enantiomeric excess (up to 90% ee) from the ketone precursor. This one-step approach in aqueous medium represents the shortest synthesis route from achiral starting materials. Furthermore, we demonstrate for the first time that tertiary amines also can be accessed by this route, which provides new opportunities for eco-friendly enzymatic asymmetric syntheses of these important molecules.

Graphical abstract: One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

Back to tab navigation

Supplementary files

Article information


Submitted
02 Nov 2016
Accepted
16 Dec 2016
First published
23 Dec 2016

Green Chem., 2017,19, 385-389
Article type
Communication

One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

P. Matzel, M. Gand and M. Höhne, Green Chem., 2017, 19, 385
DOI: 10.1039/C6GC03023H

Social activity

Search articles by author

Spotlight

Advertisements