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Issue 12, 2017
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Orange juice modulates proinflammatory cytokines after high-fat saturated meal consumption

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Abstract

We aimed to evaluate the postprandial secretion of inflammatory markers induced by SFA or MUFA high-fat meal consumption and whether orange juice intake could modulate this induction. This study included 55 healthy women (aged 20 to 40 years): 33 participants received an SFA high-fat meal (≈1000 kcal, 37.6% of energy intake (E) from SFA) and 22 participants received an MUFA high-fat meal (≈1000 kcal, 56.3% E from MUFA). Both interventions were accompanied by 500 ml of orange juice (test) or water (control). The plasma concentrations of inflammatory cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ, and TNF-α) and CRP were determined before (fasting) and 2, 3 and 5 hours after the test meal intake. The SFA high-fat meal induced a significant increase in AUC values (for TNF-α, IL-12, IL-10, IL-6 and IL-2 adjusted for baseline concentrations) in comparison with MUFA high-fat meal intervention. The results were independent of the drink which accompanied the meal (water or orange juice). Both IL-4 and IL-17A AUC values were significantly increased after an SFA high-fat meal intake, accompanied by water, but not by orange juice. In addition, these values were higher in relation to MUFA high-fat meal interventions. Also, IL-17A significantly increased at 3 h after an SFA high-fat meal intake accompanied by water, but not by orange juice. Overall, our conclusions indicate an anti-inflammatory effect of MUFA compared to SFA high-fat meal intake, while orange juice intake was able to mitigate the subclinical increase of postprandial inflammation, induced by SFA high-fat meal consumption, for a particular biomarker (IL-17A).

Graphical abstract: Orange juice modulates proinflammatory cytokines after high-fat saturated meal consumption

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Article information


Submitted
27 Jul 2017
Accepted
27 Sep 2017
First published
28 Sep 2017

Food Funct., 2017,8, 4396-4403
Article type
Paper

Orange juice modulates proinflammatory cytokines after high-fat saturated meal consumption

D. M. U. P. Rocha, L. L. Lopes, A. da Silva, L. L. Oliveira, J. Bressan and H. H. M. Hermsdorff, Food Funct., 2017, 8, 4396
DOI: 10.1039/C7FO01139C

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