Jump to main content
Jump to site search

Issue 41, 2017
Previous Article Next Article

The design of synthetic superoxide dismutase mimetics: seven-coordinate water soluble manganese(ii) and iron(ii) complexes and their superoxide dismutase-like activity studies

Author affiliations

Abstract

Bio-inspired manganese [Mn(N5Py)(H2O)(CH3OH)](ClO4)2 (1) and iron [Fe(N5Py)(H2O)(ClO4)]ClO4 (2) complexes derived from a pentadentate ligand (N5Py = 2,6-bis((E)-1-phenyl-2-(pyridin-2-ylmethylene)hydrazinyl)pyridine) framework containing a N5 binding motif were synthesized and characterized using different spectroscopic methods. The molecular structures of complexes 1 and 2 were determined by X-ray crystallography. These complexes were found to be stable under physiological conditions and exhibited an excellent superoxide dismutase (SOD) activity. The SOD activity was determined by a xanthine–xanthine oxidase–nitro blue tetrazolium assay and the IC50 values were determined to be 1.53 and 2.09 μM, respectively.

Graphical abstract: The design of synthetic superoxide dismutase mimetics: seven-coordinate water soluble manganese(ii) and iron(ii) complexes and their superoxide dismutase-like activity studies

Back to tab navigation

Supplementary files

Article information


Submitted
04 Sep 2017
Accepted
22 Sep 2017
First published
25 Sep 2017

Dalton Trans., 2017,46, 14186-14191
Article type
Paper

The design of synthetic superoxide dismutase mimetics: seven-coordinate water soluble manganese(II) and iron(II) complexes and their superoxide dismutase-like activity studies

O. Singh, N. Tyagi, M. M. Olmstead and K. Ghosh, Dalton Trans., 2017, 46, 14186 DOI: 10.1039/C7DT03278A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements