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Issue 9, 2017
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Assessing cooperativity in supramolecular systems

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Abstract

This tutorial review summarises different aspects of cooperativity in supramolecular complexes. We propose a systematic categorisation of cooperativity into cooperative aggregation, intermolecular (allosteric) cooperativity, intramolecular (chelate) cooperativity and interannular cooperativity and discuss approaches to quantify them thermodynamically using cooperativity factors. A brief summary of methods to determine the necessary thermodynamic data is given with emphasis on isothermal titration calorimetry (ITC), a method still underrepresented in supramolecular chemistry, which however offers some advantages over others. Finally, a discussion of very few selected examples, which highlight different aspects to illustrate why such an analysis is useful, rounds up this review.

Graphical abstract: Assessing cooperativity in supramolecular systems

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Article information


Submitted
06 Feb 2017
First published
29 Mar 2017

Chem. Soc. Rev., 2017,46, 2622-2637
Article type
Review Article

Assessing cooperativity in supramolecular systems

L. K. S. von Krbek, C. A. Schalley and P. Thordarson, Chem. Soc. Rev., 2017, 46, 2622
DOI: 10.1039/C7CS00063D

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