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Issue 6, 2017
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Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis

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Abstract

Recent advancement in the area of asymmetric organocatalysis led to the development of new methodologies for the construction of valuable enantiopure molecules, including various heterocycles. As one of the latter class of compounds tetrahydropyrans (THPs) constitute a core structure of a wide array of bioactive natural products. A noticeable growth has been observed in the asymmetric synthesis of THPs using small organic molecules as catalysts. This Tutorial Review describes the organocatalytic methods available to furnish THPs as well as the application of these methodologies in the total synthesis of THP-based natural products.

Graphical abstract: Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis

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Article information


Submitted
21 Oct 2016
First published
06 Mar 2017

Chem. Soc. Rev., 2017,46, 1661-1674
Article type
Tutorial Review

Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis

F. Vetica, P. Chauhan, S. Dochain and D. Enders, Chem. Soc. Rev., 2017, 46, 1661
DOI: 10.1039/C6CS00757K

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