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Issue 99, 2017
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5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase

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Abstract

DNA templates containing 5-hydroxymethyluracil or 5-hydroxymethylcytosine were used in an in vitro transcription assay with RNA polymerase from Escherichia coli. A strong enhancement of transcription was observed from DNA containing the Pveg promoter whereas a decrease was observed from DNA containing the rrnB P1 promoter, suggesting that they may act as epigenetic marks.

Graphical abstract: 5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase

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Supplementary files

Article information


Submitted
18 Oct 2017
Accepted
21 Nov 2017
First published
22 Nov 2017

This article is Open Access

Chem. Commun., 2017,53, 13253-13255
Article type
Communication

5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase

M. Janoušková, Z. Vaníková, F. Nici, S. Boháčová, D. Vítovská, H. Šanderová, M. Hocek and L. Krásný, Chem. Commun., 2017, 53, 13253
DOI: 10.1039/C7CC08053K

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