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Issue 100, 2017
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A small molecule for theraNOstic targeting of cancer cells

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Abstract

Thera/NO – a small molecule that is activated by hydrogen peroxide to generate nitric oxide (NO) and a fluorescence signal is reported. Using cancer and primary cells, we show that Thera/NO preferentially releases NO in cancer cells, which can trigger DNA damage and cell death in them. The coupled fluorescence signal facilitated tracking the NO release in living cells without collateral consumption of NO.

Graphical abstract: A small molecule for theraNOstic targeting of cancer cells

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Supplementary files

Article information


Submitted
06 Nov 2017
Accepted
20 Nov 2017
First published
20 Nov 2017

Chem. Commun., 2017,53, 13352-13355
Article type
Communication

A small molecule for theraNOstic targeting of cancer cells

G. Ravikumar, M. Bagheri, D. K. Saini and H. Chakrapani, Chem. Commun., 2017, 53, 13352
DOI: 10.1039/C7CC08526E

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