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Issue 95, 2017
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Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

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Abstract

Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).

Graphical abstract: Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

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Supplementary files

Article information


Submitted
10 Oct 2017
Accepted
03 Nov 2017
First published
08 Nov 2017

This article is Open Access

Chem. Commun., 2017,53, 12822-12825
Article type
Communication

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

A. C. Sedgwick, H. Han, J. E. Gardiner, S. D. Bull, X. He and T. D. James, Chem. Commun., 2017, 53, 12822
DOI: 10.1039/C7CC07845E

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