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Issue 83, 2017
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A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding

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Abstract

By functionalizing triarylboron with cyclen, we developed a two-photon fluorescence probe, TAB-2, which can selectively bind RNA with a ratiometric readout. We tested TAB-2 in NIH/3T3 fibroblast cells, and demonstrated its capability in visualizing nucleoli and analyzing microenvironment polarity by two-photon and fluorescence-lifetime imaging microscopy.

Graphical abstract: A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding

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Supplementary files

Article information


Submitted
02 Aug 2017
Accepted
02 Oct 2017
First published
02 Oct 2017

Chem. Commun., 2017,53, 11476-11479
Article type
Communication

A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding

J. Liu, S. Zhang, C. Zhang, J. Dong, C. Shen, J. Zhu, H. Xu, M. Fu, G. Yang and X. Zhang, Chem. Commun., 2017, 53, 11476 DOI: 10.1039/C7CC06045A

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