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Issue 92, 2017
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Palladium catalyzed direct aliphatic γC(sp3)–H alkenylation with alkenes and alkenyl iodides

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Abstract

The catalytic alkenylation of the unactivated distal γC(sp3)–H bonds of aliphatic acids with simple acrylates and vinyl iodides is described. This method allows for the introduction of an alkene group into aliphatic acid derivatives in the form of activated olefins and vinyl iodides. Notably, olefination with vinyl iodides provides access to a wide range of challenging γ-vinyl acid derivatives with aliphatic olefin functionality introduced in a diastereoselective manner.

Graphical abstract: Palladium catalyzed direct aliphatic γC(sp3)–H alkenylation with alkenes and alkenyl iodides

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Article information


Submitted
22 Jul 2017
Accepted
26 Oct 2017
First published
26 Oct 2017

Chem. Commun., 2017,53, 12457-12460
Article type
Communication

Palladium catalyzed direct aliphatic γC(sp3)–H alkenylation with alkenes and alkenyl iodides

N. Thrimurtulu, S. Khan, S. Maity, C. M. R. Volla and D. Maiti, Chem. Commun., 2017, 53, 12457
DOI: 10.1039/C7CC05703B

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