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Issue 71, 2017
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Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques

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Abstract

Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-β plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood–brain barrier and efficiently differentiate the living transgenic and wild-type mice.

Graphical abstract: Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques

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Publication details

The article was received on 30 Jun 2017, accepted on 10 Aug 2017 and first published on 14 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05056A
Chem. Commun., 2017,53, 9910-9913

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    Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques

    J. Yan, J. Zhu, K. Zhou, J. Wang, H. Tan, Z. Xu, S. Chen, Y. Lu, M. Cui and L. Zhang, Chem. Commun., 2017, 53, 9910
    DOI: 10.1039/C7CC05056A

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