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Issue 69, 2017
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Discovery of synthetic small molecules that enhance the number of stomata: C–H functionalization chemistry for plant biology

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Abstract

The increasing climate changes and global warming are leading to colossal agricultural problems such as abatement of food production and quality. As stomatal development is considered to play a key role in crop plant productivity and water-use efficiency, studying stomatal development is useful for understanding the productivity of plant systems for both natural and agricultural systems. Herein, we report the first-in-class synthetic small molecules enhancing the number of stomata in Arabidopsis thaliana that have been discovered by screening of the chemical library and further optimized by the Pd-catalyzed C–H arylation reaction. The present study shows not only huge potential of small molecules to control the cellular and developmental processes of stomata without using genetically modified plants, but also the power of C–H functionalization chemistry to rapidly identify the optimized compounds.

Graphical abstract: Discovery of synthetic small molecules that enhance the number of stomata: C–H functionalization chemistry for plant biology

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Supplementary files

Article information


Submitted
11 Jun 2017
Accepted
07 Aug 2017
First published
15 Aug 2017

Chem. Commun., 2017,53, 9632-9635
Article type
Communication

Discovery of synthetic small molecules that enhance the number of stomata: C–H functionalization chemistry for plant biology

A. Ziadi, N. Uchida, H. Kato, R. Hisamatsu, A. Sato, S. Hagihara, K. Itami and K. U. Torii, Chem. Commun., 2017, 53, 9632
DOI: 10.1039/C7CC04526C

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