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Issue 63, 2017
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A DNA nanoribbon as a potent inhibitor of metallo-β-lactamases

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Abstract

We discovered a promising metallo-β-lactamase inhibitor, a DNA nanoribbon, by enzymatic kinetics and isothermal titration calorimetry evaluations. Atomic force microscopy, gel electrophoresis, competitive binding experiments, circular dichroic and thermal denaturation studies suggested that the DNA nanoribbon could bind to the enzyme through a minor groove.

Graphical abstract: A DNA nanoribbon as a potent inhibitor of metallo-β-lactamases

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Publication details

The article was received on 09 Jun 2017, accepted on 17 Jul 2017 and first published on 17 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04483F
Chem. Commun., 2017,53, 8878-8881

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    A DNA nanoribbon as a potent inhibitor of metallo-β-lactamases

    X. Ouyang, Y. Chang, K. Yang, W. Wang, J. Bai, J. Wang, Y. Zhang, S. Wang, B. Xie and L. Wang, Chem. Commun., 2017, 53, 8878
    DOI: 10.1039/C7CC04483F

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