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Issue 60, 2017
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l-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

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Abstract

L-Lysines were conjugated to lipidated biphenyls using simple synthetic chemistry to obtain selective membrane-active antibacterial agents that inhibit cell-wall biosynthesis. The most selective compound bore promising activity against biofilm-related infections and intracellular bacteria, and also suppressed the stimulation of TNF-α induced by lipoteichoic acid. Belligerent to resistance development, it was active in a murine model of MRSA infection.

Graphical abstract: l-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

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Supplementary files

Article information


Submitted
08 Jun 2017
Accepted
30 Jun 2017
First published
30 Jun 2017

Chem. Commun., 2017,53, 8427-8430
Article type
Communication

L-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

C. Ghosh, P. Sarkar, S. Samaddar, D. S. S. M. Uppu and J. Haldar, Chem. Commun., 2017, 53, 8427
DOI: 10.1039/C7CC04206J

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