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Issue 54, 2017
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Facile access to 2,2-disubstituted indolin-3-ones via a cascade Fischer indolization/Claisen rearrangement reaction

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Abstract

An efficient approach for the synthesis of 2,2-disubstituted indolin-3-ones is described. From readily accessible aryl hydrazines and allyloxyketones, 2,2-disubstituted indolin-3-ones could be obtained in good to excellent yields under mild reaction conditions via a cascade Fischer indolization/Claisen rearrangement process. This protocol provides a facile entry to 2,2-disubstituted indolin-3-ones, which have been applied in the construction of the benzofuroindoline framework related to Phalarine.

Graphical abstract: Facile access to 2,2-disubstituted indolin-3-ones via a cascade Fischer indolization/Claisen rearrangement reaction

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Article information


Submitted
15 May 2017
Accepted
09 Jun 2017
First published
12 Jun 2017

Chem. Commun., 2017,53, 7485-7488
Article type
Communication

Facile access to 2,2-disubstituted indolin-3-ones via a cascade Fischer indolization/Claisen rearrangement reaction

Z. Xia, J. Hu, Y. Gao, Q. Yao and W. Xie, Chem. Commun., 2017, 53, 7485
DOI: 10.1039/C7CC03754F

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