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Issue 56, 2017
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Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

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Abstract

The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

Graphical abstract: Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

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Publication details

The article was received on 28 Apr 2017, accepted on 23 Jun 2017 and first published on 23 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC03303F
Chem. Commun., 2017,53, 7965-7968

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    Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

    K. Williams, A. J. Szwalbe, C. Dickson, T. R. Desson, N. P. Mulholland, J. L. Vincent, J. M. Clough, A. M. Bailey, C. P. Butts, C. L. Willis, T. J. Simpson and R. J. Cox, Chem. Commun., 2017, 53, 7965
    DOI: 10.1039/C7CC03303F

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