Jump to main content
Jump to site search

Issue 45, 2017
Previous Article Next Article

Palladium-catalysed atom-economical synthesis of conjugated dienals from terminal acetylenes and acrolein

Author affiliations

Abstract

Conjugated (E,E)-dienals are versatile synthetic intermediates owing to their trifunctional, electrophilic nature and the prevalence of the (E,E)-diene in a wide range of functional molecules. It is shown herein that (E,E)-dienals can be readily prepared in two palladium-catalysed steps from simple, unactivated starting materials; terminal acetylenes and acrolein can be coupled via conjugate addition, followed by alkyne isomerisation. This procedure provides a highly atom-economical, redox-neutral and practical method to prepare a range of conjugated (E,E)-dienals in good yields and diastereoselectivities.

Graphical abstract: Palladium-catalysed atom-economical synthesis of conjugated dienals from terminal acetylenes and acrolein

Back to tab navigation

Supplementary files

Article information


Submitted
13 Apr 2017
Accepted
11 May 2017
First published
12 May 2017

Chem. Commun., 2017,53, 6136-6139
Article type
Communication

Palladium-catalysed atom-economical synthesis of conjugated dienals from terminal acetylenes and acrolein

Z. Hearne and C. Li, Chem. Commun., 2017, 53, 6136 DOI: 10.1039/C7CC02767B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements