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Issue 52, 2017
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Novel chemical probes for the investigation of nonribosomal peptide assembly

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Abstract

Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.

Graphical abstract: Novel chemical probes for the investigation of nonribosomal peptide assembly

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Submitted
30 Mar 2017
Accepted
12 Jun 2017
First published
19 Jun 2017

This article is Open Access

Chem. Commun., 2017,53, 7088-7091
Article type
Communication

Novel chemical probes for the investigation of nonribosomal peptide assembly

Y. T. C. Ho, D. J. Leng, F. Ghiringhelli, I. Wilkening, D. P. Bushell, O. Köstner, E. Riva, J. Havemann, D. Passarella and M. Tosin, Chem. Commun., 2017, 53, 7088
DOI: 10.1039/C7CC02427D

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