Novel chemical probes for the investigation of nonribosomal peptide assembly

Y. T. Candace Ho; Daniel J. Leng; Francesca Ghiringhelli; Ina Wilkening; Dexter P. Bushell; Otto Köstner; Elena Riva; Judith Havemann; Daniele Passarella; Manuela Tosin

doi:10.1039/C7CC02427D

Novel chemical probes for the investigation of nonribosomal peptide assembly†

Y. T. Candace Ho,^a Daniel J. Leng,^a Francesca Ghiringhelli,^ab Ina Wilkening,^a Dexter P. Bushell,^a Otto Köstner,^ac Elena Riva,^a Judith Havemann,^a Daniele Passarella

^b and Manuela Tosin

*^a

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* Corresponding authors

^a Department of Chemistry, University of Warwick, Library Road, UK
E-mail: M.Tosin@warwick.ac.uk
Tel: +442476572878

^b Department of Chemistry, Universita' degli Studi di Milano, Via Golgi, 19 20133 Milano, Italy

^c Institut für Organische Chemie, Universität Wien, Währinger Str., 38 1090 Wien, Austria

Abstract

Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.

Chemical Communications

Novel chemical probes for the investigation of nonribosomal peptide assembly†

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Novel chemical probes for the investigation of nonribosomal peptide assembly

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