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Issue 46, 2017
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A deciduous directing group approach for the addition of aryl and vinyl nucleophiles to maleimides

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Abstract

A Rh(III)-catalyzed C–H activation followed by conjugate addition to maleimides, using carboxylic acid as a traceless/deciduous directing group, to formally furnish a Csp2–Csp3 bond is presented. For the first time, derivatives of acrylic acid have been shown as surrogates for the unstable and expensive alkenyl boronic acids.

Graphical abstract: A deciduous directing group approach for the addition of aryl and vinyl nucleophiles to maleimides

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Supplementary files

Article information


Submitted
28 Mar 2017
Accepted
15 May 2017
First published
15 May 2017

Chem. Commun., 2017,53, 6251-6254
Article type
Communication

A deciduous directing group approach for the addition of aryl and vinyl nucleophiles to maleimides

K. R. Bettadapur, V. Lanke and K. R. Prabhu, Chem. Commun., 2017, 53, 6251 DOI: 10.1039/C7CC02392H

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