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Issue 29, 2017
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Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex

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Abstract

An addressable single cell imaging strategy combining ToF-SIMS and confocal fluorescence microscopy imaging has been developed, and sucessfully applied to visualize the subcellular distribution of an organoruthenium anticancer complex, [(η6-benzene)Ru(N,N-L)Cl]+ (1; L: 4-anilinoquinazoline ligand), showing its accumulation in both cell membrane and nuclei, and verifying its dual-targeting feature.

Graphical abstract: Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex

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Publication details

The article was received on 25 Feb 2017, accepted on 22 Mar 2017 and first published on 22 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC01503H
Chem. Commun., 2017,53, 4136-4139

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    Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex

    S. Liu, W. Zheng, K. Wu, Y. Lin, F. Jia, Y. Zhang, Z. Wang, Q. Luo, Y. Zhao and F. Wang, Chem. Commun., 2017, 53, 4136
    DOI: 10.1039/C7CC01503H

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