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Issue 26, 2017
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A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity

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Abstract

The first two-photon probe, Lyso-OC, was proposed for use in monitoring cell autophagy by detection of the change in the lysosomal polarity during the membrane fusion process of autophagy. The Lyso-OC probe exhibited desirable optical properties and a detection signal that was selective to the polarity change. More importantly, Lyso-OC displayed real-time monitoring of autophagy in living cells.

Graphical abstract: A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity

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Supplementary files

Article information


Submitted
27 Jan 2017
Accepted
17 Feb 2017
First published
17 Feb 2017

Chem. Commun., 2017,53, 3645-3648
Article type
Communication

A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity

J. Jiang, X. Tian, C. Xu, S. Wang, Y. Feng, M. Chen, H. Yu, M. Zhu and X. Meng, Chem. Commun., 2017, 53, 3645 DOI: 10.1039/C7CC00752C

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