Issue 24, 2017
From the journal:

Chemical Communications

In vitro selection of random peptides against artificial lipid bilayers: a potential tool to immobilize molecules on membranes†

Shota Kobayashi,‡a   Takuya Terai, ORCID logo ‡a   Yuki Yoshikawa,a   Ryoya Ohkawa,a   Mika Ebihara,a   Masahito Hayashi,b   Kingo Takiguchib  and  Naoto Nemoto*a  

* Corresponding authors

a Graduate School of Science and Engineering, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 338-8570, Japan
E-mail: nemoto@fms.saitama-u.ac.jp

b Division of Biological Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan

Abstract

The first in vitro selection of binding peptides against artificial lipid membranes from a random peptide library using an in vitro display method (cDNA display) is reported. The selected peptide, LB-1, has both amphiphilic and cationic regions, and proteins fused to LB-1 can be immobilized on the liposome surface.

Graphical abstract: In vitro selection of random peptides against artificial lipid bilayers: a potential tool to immobilize molecules on membranes

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Article information

DOI
https://doi.org/10.1039/C7CC00099E
Article type
Communication
Submitted
06 Jan 2017
Accepted
16 Feb 2017
First published
08 Mar 2017

Chem. Commun., 2017,53, 3458-3461

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In vitro selection of random peptides against artificial lipid bilayers: a potential tool to immobilize molecules on membranes

S. Kobayashi, T. Terai, Y. Yoshikawa, R. Ohkawa, M. Ebihara, M. Hayashi, K. Takiguchi and N. Nemoto, Chem. Commun., 2017, 53, 3458 DOI: 10.1039/C7CC00099E

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