Issue 13, 2017
From the journal:

Chemical Communications

N–N bond formation in Ugi processes: from nitric acid to libraries of nitramines†

Valentina Mercalli,ab   Aude Nyadanu,acd   Marie Cordier,e   Gian Cesare Tron,*b   Laurence Grimaud*cd  and  Laurent El Kaim ORCID logo *a  

* Corresponding authors

a Laboratoire de Synthèse Organique, CNRS, Ecole Polytechnique, ENSTA ParisTech- UMR 7652, Université Paris-Saclay, 828 Bd des Maréchaux, 91128 Palaiseau, France
E-mail: laurent.elkaim@ensta-paristech.fr

b Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale “A. Avogadro”, largo Donegani 2, 28100 Novara, Italy
E-mail: giancesare.tron@uniupo.it

c Ecole normale supérieure, PSL Research University, UPMC Univ Paris 06, CNRS, Département de Chimie, PASTEUR, 24, rue Lhomond, 75005 Paris, France

d Sorbonne Universités, UPMC Univ Paris 06, ENS, CNRS, PASTEUR, 75005 Paris, France
E-mail: Laurence.grimaud@ens.fr

e Laboratoire de Chimie Moléculaire, UMR 9168, Department of Chemistry, Ecole Polytechnique, CNRS, Palaiseau Cedex, France

Abstract

The Ugi reaction has drawn considerable attention over the years leading to numerous libraries of heterocycles and various extensions changing the nature of the components of the coupling. We report here the use of nitric acid as carboxylic acids surrogates, displaying the first aminative Ugi-type reaction leading to nitramines.

Graphical abstract: N–N bond formation in Ugi processes: from nitric acid to libraries of nitramines

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Article information

DOI
https://doi.org/10.1039/C6CC10288C
Article type
Communication
Submitted
28 Dec 2016
Accepted
20 Jan 2017
First published
20 Jan 2017

Chem. Commun., 2017,53, 2118-2121

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N–N bond formation in Ugi processes: from nitric acid to libraries of nitramines

V. Mercalli, A. Nyadanu, M. Cordier, G. C. Tron, L. Grimaud and L. El Kaim, Chem. Commun., 2017, 53, 2118 DOI: 10.1039/C6CC10288C

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